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James N. Antezana, MD

Chief Endovascular Surgeon
South Charlotte General & Vascular Surgery
Charlotte, North Carolina, United States

Dr. James N. Antezana is a board-certified vascular and general surgeon, founder and CEO of South Charlotte General & Vascular Surgery, and a recognized leader in advanced endovascular and limb salvage therapy. Based in Charlotte, North Carolina, he specializes in complex arterial and venous disease, with particular expertise in catheter-based revascularization, venous stenting, and office-based vascular interventions.

Dr. Antezana is known for his work in treating advanced peripheral arterial disease, including Rutherford category 4–6 patients, utilizing cutting-edge techniques such as intravascular ultrasound (IVUS), laser atherectomy, pedal access, and multi-level endovascular reconstruction. His approach emphasizes precision, minimally invasive strategies, and durable outcomes in high-risk populations.

In addition to his clinical work, Dr. Antezana is an innovator in healthcare delivery models. He has developed and expanded high-performance office-based labs (OBLs) and ambulatory surgical centers (ASCs), focusing on efficiency, patient-centered care, and physician-led systems. His work integrates clinical excellence with strategic infrastructure, positioning vascular specialists to deliver comprehensive care outside the traditional hospital setting.

Dr. Antezana is also actively involved in the development of advanced medical technologies, including next-generation implantable devices and integrated imaging platforms. He is a frequent speaker at national and international conferences, where he shares insights on complex endovascular techniques, venous disease management, and the evolving business of vascular care.

Through his work, Dr. Antezana continues to advance the field of vascular surgery by bridging innovation, technical mastery, and system-level transformation.

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